As a follow up to this thread: iOS 9 lightening to USB audio clicks and pops

SITUATION
iPhone 6S Plus, iOS 9.2, Opel Ampera/Chevy Volt, Original Apple Lightning-USB cable

ISSUE
Distorted audio - stuttering and seek/skip like sounds - will occur when playing audio files over a Lightning to USB connection. 
The issue will arise anywhere between 3 and 15 minutes into a track or audio file. The issue will arise only when the phone is locked.

REPRODUCTION
1. Play a long audio file (>5 minutes) on a LOCKED iPhone running iOS 9.2 and wait for the audio to distort.
2a. Once the issue occurs, UNLOCK the phone and the issue will be resolved immediately.
2b. PAUSING the playback and waiting around 5-10 seconds until playing again will also resolve the issue temporarily.
3. Once the phone is LOCKED again (either auto-lock or manual) the issue will come back immediately.

NOTES
The issue can be predominantly heard using spoken word media. 
The issue will happen with music, but due to high dynamics certain music types can have, the issue might be less noticeable.

If you have a similair issue, please post your findings in this topic.

iPhone 6s Plus, iOS 9.2